This weeks personal choice is the J. Med. Chem. perspective Using Deuterium in Drug Discovery: Leaving the Label in the Drug composed by Thomas Gant of Recondite Falls Discovery, LLC in Pennsylvania USA. This is a wonderfully written perspective by an expert in the field, taking us through the chemistry of deuterium’s use from the simple right up to the complex phase III studies providing wonderful thought provoking examples along the way.
Deuterium is already utilised in the pharma. industry normally as a standard in mass spectrometry. or for the purpose of finding a solution to mechanistic problems. The author points out that the chemistry of deuterium incorporation can be very simple or very complex. I chose the simple route for a couple of my compounds, the saturation of a C=C bond with deuterium as a prelude to tritiation of the compound for subsequent use as a radio-label.
So have a read at this essay and perhaps you will gain some new ideas for your med. chem. programs.
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